Proof of Transplantation Technology Cure

There is proof that Tissera's pancreatic xenotransplantation has just reached an important target in its quest for treatment of type 1 diabetes. After successful pancreatic transplantation in the past, Tissera went on to investigate further the value of their treatment approach.

The Weizmann Institute of Science research team treated human primates with streptozotocin to make them diabetic and dependent on the administration of insulin to maintain sensible blood glucose levels. After a stabilization period, the research team transplanted a pig embryonic pancreatic tissue into these primates.

The scientists then followed these cases up. They reduced the amount of insulin they administered. By the fourth month after they transplanted the pancreatic tissue, only 10% of insulin was needed to maintain near normal blood glucose levels. And by the fifth month, the diabetic primates reached complete independence.

For this research, the scientists also addressed the issue of graft rejection. They were able to reduce the immune suppression treatment to counteract the rejection of the graft. The dose is down to the level adequate for humans with less side effects.

Even with the lower dose of immune suppression treatment, the primate achieved complete insulin independence 18 weeks after the transplantation. After 31 weeks from transplantation, the primate is well and is still completely independent from the administration of insulin.

This is an important achievement in the company's plan to reduce the immune suppression procedure which could make it possible to use on humans. There is therefore proof that this company's way to treat type 1 diabetes has therapeutic value.

Chairman and CEO of Tissera said they are so encouraged by the results of their study that they are having more studies to move forward with their goal of making this future treatment possible for people with type 1 diabetes in the very near future.

I researched this company because of its reported success on the pancreatic transplantation in the hope that they have finally zeroed in on a permanent cure for diabetics. The last I heard was that they are still basking on the significant milestone they accomplished on the large animal diabetic model experiments.