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Monday, August 23, 2010

Diabetes Status Affects Brain Damage in Dementia

Diabetes therapy helpful in dementia? The finding of this study is definitely helpful in determining what to do therapeutically speaking as it is quite revealing how different the injury patterns are between those who have diabetes and those without. This is why we take good care of ourselves. I can't wait to hear what the researchers will do as this opens up doors for discovering treatment options.

Dementia patients who were elderly and were with or without diabetes seem to have definite patterns of cerebral damage. This is according to the study findings that were published in the Archives of Neurology. University of Washington's Joshua A. Sonnen, M.D. in Seattle and his colleagues conducted a wide-ranging neuropathologic evaluation of 259 participants in a community-based study of incident dementia.

The participants underwent autopsies, including 196 with known diabetes status. Among those without dementia, the researchers found that biochemical and neuropathologic end points were the same in the diabetics and those without diabetes.

But among the 71 participants with dementia, the researchers found that the diabetics whose diabetes was treated tended to have more microvascular infarcts. They also had a higher concentration of cortical interleukin-6. Those without diabetics and had dementia tended to have more amyloid-beta peptide. They also had increased levels of F2-isoprostanes in the cerebral cortex.

Among the participants who had dementia and whose diabetes was untreated tended to have more amyloid plaque load. These new characterizations of two different patterns of injury depending on whether they have diabetes or not may have some implications treatment-wise.

The researchers tested the hypothesis that diabetes leads to definite neuropathologic procedures that is a factor to the development of dementia and that this could be suppressed by anti diabetic treatment. That is why they concluded that their findings may have some implications in diabetes therapy.

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